Does Zoloft Trigger Weight Achieve? — Talkspace

, also referred to as sertraline, is an antidepressant medicine used to deal with melancholy, anxiousness, and different psychological well being circumstances. Whereas this selective serotonin reuptake inhibitor (SSRI) will be an efficient therapy of melancholy and for many individuals, like all drug, there are potential psychological and bodily that may include antidepressant use. A standard aspect impact is Zoloft weight achieve. 

Not everybody experiences sertraline weight achieve. A lot of the time, that physique weight achieve is modest or momentary. That stated, it’s nonetheless necessary to grasp the potential aspect impact and focus on it along with your physician earlier than beginning therapy.

Does Zoloft Trigger Weight Achieve?

Are you able to achieve weight on Zoloft? Some have proven that round 11% of people that take antidepressants expertise a weight achieve of not less than 5% through the first 12 months. Nonetheless, your unwanted effects could happen at completely different occasions relying on in your physique. Some that different varieties of antidepressants may need the next danger than Zoloft. 

“Zoloft can doubtlessly trigger weight achieve, nevertheless it’s not a vital aspect impact for everybody. It’s greatest to get readability out of your psychiatrist about which antidepressant is one of the best match for you. You will get on one other medicine if you end up gaining weight.”

What different SSRIs trigger weight achieve?

Physique weight achieve is usually a aspect impact of antidepressant use past simply Zoloft. Different selective serotonin reuptake inhibitors (SSRIs) that may trigger weight achieve embrace: 

  • Prozac
  • Paxil
  • Celexa
  • Lexapro 

Weight achieve seems to be extra probably when taking greater doses or for individuals taking the antidepressant drug for prolonged intervals.  


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Why Does Zoloft Trigger Weight Achieve?

The precise motive why you would possibly achieve weight on Zoloft isn’t totally understood, however a number of theories exist. 

Elevated serotonin ranges

One concept means that elevated serotonin ranges within the mind attributable to SSRI medicine can have an effect on metabolism and starvation indicators within the physique. This would possibly result in adjustments in urge for food and consuming habits in addition to cravings for unhealthy meals, leading to weight achieve over time. 

Power ranges

One other risk for Zoloft weight achieve is that sure varieties of melancholy medicines intervene with vitality steadiness. For some individuals, antidepressant therapy could trigger them to develop into much less energetic and burn fewer energy than they often would. 

Hormones and metabolism

Some analysis means that long-term use of SSRI medicine could alter appetite-regulating hormones like leptin and ghrelin. Extra analysis is required, although, because it’s in weight achieve.  

Sedative impact

Lastly, one other issue that might contribute to potential weight achieve from taking Zoloft is likely to be its sedative impact. Zoloft could make you’re feeling drowsy or sleepy through the day. It’s believable that this might cut back your exercise stage and enhance your probability of gaining weight because of a scarcity of bodily train.

How Can I Keep away from Gaining Weight on Zoloft?

If you happen to’re involved about Zoloft weight achieve, there are steps you may take to assist decrease this danger.

Nutritious diet

Sustaining a nutritious diet is essential to avoiding sertraline weight achieve. Consuming balanced meals with loads of fruits, greens, lean proteins, and complete grains might help you keep full longer and maintain your vitality ranges up. 

As well as, you must keep away from processed meals excessive in sugar and saturated fat, as these can result in weight achieve. It’s additionally necessary to look at portion sizes; overeating any meals kind could cause undesirable kilos.

Get shifting & be energetic

Getting energetic is one other nice option to keep away from gaining weight on Zoloft. Train helps burn energy and enhance metabolism, which is important for sustaining a wholesome weight. You don’t have to affix an costly health club or purchase fancy gear; merely strolling across the block or doing gentle stretching at dwelling will typically do the trick.

Make sleep a precedence

Making sleep a precedence is important for psychological well being generally. Lack of sleep can result in elevated urge for food because of hormones being out of steadiness, making it more durable for individuals who take this antidepressant medicine to take care of their present weight and forestall additional good points from occurring sooner or later. Preserve a wholesome sleep routine and intention for 7-8 hours per night time. You can too take brief naps all through the day.

Discuss to your physician about switching medicine

Discuss along with your physician about switching your antidepressant therapy if vital. 

“One of the best ways to keep away from weight achieve because of Zoloft is to work intently along with your psychiatrist. If you end up gaining weight, let your physician know so that you will be switched to a different antidepressant.”

In case your and therapy plan advocate , your physician could possibly advocate different SSRIs which can be much less more likely to trigger weight achieve.

Discuss to Your Physician About Zoloft Aspect Results

It’s essential for anybody contemplating beginning an antidepressant like Zoloft to grasp the dangers related to its use. 

If you happen to’re apprehensive about Zoloft and weight achieve or different unwanted effects, share your issues along with your physician.

from Talkspace can present skilled steering as you navigate the potential unwanted effects of a prescribed medicine. If you happen to’re involved with weight achieve on Zoloft, discover your therapy choices with a psychiatrist. Take management of your well being at present by looking for the best for you.


  1. Arterburn D, Sofer T, Boudreau D, et al. Lengthy-term weight change after initiating second-generation antidepressants. Journal of Medical Drugs. 2016;5(4):48. doi:10.3390/jcm5040048. . Accessed December 16, 2022.
  2. Gafoor R, Sales space HP, Gulliford MC. Antidepressant utilization and incidence of weight achieve throughout 10 years’ follow-up: Inhabitants primarily based cohort examine. BMJ. 2018. doi:10.1136/bmj.k1951. . Accessed December 16, 2022.
  3. Ozsoy S, Besirli A, Abdulrezzak U, Basturk M. Serum ghrelin and leptin ranges in sufferers with melancholy and the consequences of therapy. Psychiatry Investigation. 2014;11(2):167. doi:10.4306/pi.2014.11.2.167. . Accessed December 16, 2022.

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