Course: The Human Microbiome in Well being and Illness

In collaboration with the Primal Well being Coach Institute, I’ve put collectively a complete instructional course on the microbiome known as The Human Microbiome in Well being and Illness. The course is designed for well being coaches to empower them in advising purchasers and sufferers on points microbiome. It’s, I consider, essentially the most complete and full course of its form. Whereas designed for well being coaches, it will possibly additionally present deep training on all microbiome points for different well being professionals, physicians, or the well-informed citizen scientist or anybody with a deep curiosity in these essential points.

As a result of the science exploring the human microbiome is rising so quickly, most individuals in healthcare have change into helplessly out-of-date. But insights into the microbiome are proving to be one of the essential revolutions in well being to emerge in a few years. It’s altering virtually all the things we thought we knew about well being and illness, re-defining well being circumstances as frequent as kind 2 diabetes, weight problems, hypertension, coronary heart illness, colon most cancers, and cognitive impairment.

The course is delivered over 9 modules, every beginning with a video overview, contains graphics and diagrams, well being teaching suggestions, and chosen references for additional exploration. Word that Members of my Internal Circle may even be offered entry to an identical, expanded course near-future.

Right here is the final format of the course:

Module 1: Overview
Primary gastrointestinal (GI) anatomy and physiology from a microbiome perspective
Microbiome in well being—places, concentrations, species: micro organism, archaea, fungi, viruses, phages
Microbiome in illness—main, secondary; causative or exacerbating roles; metabolites
Strategies of evaluation—stool microbiome evaluation; breath testing; empiric strategies
Why the science has progressed quickly simply over the previous decade—tradition strategies, 16s rRNA sequencing, shotgun metagenomics
Human Microbiome Challenge, Meta-HIT
Why examine the microbiome, what well being benefits are potential?

Module 2: Primary microbiology
Micro organism, fungi, archaea, bacteriophages
Gram constructive, Gram unfavorable
Asexual replica, fermentation
Lipopolysaccharide, lipoteichoic acid, beta glucan
Introduction to endotoxemia and translocation

Module 3: Human GI anatomy and physiology from a microbiome perspective
Mouth, tooth, oropharynx—salivary elements; reservoir of microbes in regular vs. decay/gingivitis/periodontitis
Esophagus—propulsive motion, esophageal sphincter
Abdomen—Function of abdomen acid, parietal cells, H pylori, intrinsic issue
Duodenum—frequent bile duct, cholecystokinin, alkalization, bile, pancreatic enzymes; susceptibility to microbial disruption
Jejunum, ileum—mucus barrier, intestinal immune system, myenteric nervous system, vagus nerve; distinctive microbial setting; migrating motor advanced—is that this an actual difficulty?
Colon—cecum, appendix, ascending, transverse, descending, sigmoid

Module 4: Gastrointestinal microbiome in well being
Is there such a factor as a “wholesome microbiome”? Judgements based mostly on assessments of indigenous hunter-gatherer populations—Do they characterize the optimum scenario or variations to native environments?
Wholesome trendy microbial populations—GI places, concentrations, and capabilities of micro organism, fungi, archaea
Capabilities—intestinal mucus stimulation, competitors with pathogens, meals processing, participation in intestinal immune operate
Quick-chain fatty acid metabolites
Vitamin metabolites—B nutritional vitamins, K2
Bile acid metabolites—position of taurine, glycine; bile salt hydrolase
Idea of keystone species and position in sustaining a wholesome microbiome
Evolution of the microbiome from beginning, to infancy, to early childhood, to maturity, to aged
Modifications related to being pregnant and lactation
Fundamentals of gastrointestinal mucus

Module 5: The disrupted microbiome and its position in human illness
Core microbiota; relative populations of Bacteroidetes, Firmicutes, Actinobacteria, Proteobacteria, and Verrucomicrobia; adjustments in species composition
Overgrowth of micro organism, fungi, archaea
Key markers—Bacteroidetes/firmicutes ratio; proportion Verrucomicrobia/Akkermansia; proportion Faecalibacterium prausnitzii; Fusobacterium nucleatum; Ruminococcaceae, Lachnospiraceae, Clostridia; Proteobacteria—E. coli, Klebsiella, Enterobacter, and many others.; Gram positives—Staphylococcus, Streptococcus, Enterococcus
Elements that disrupt microbiome composition—antibiotics, different prescribed drugs, meals components (emulsifiers, preservatives) herbicides/pesticides, glyphosate, chlorinated ingesting water, artificial sweeteners, stress, electromagnetic frequencies?
Penalties of lack of prebiotic fibers and different microbial vitamins
Modifications in species location—colon vs small bowel, bacterial translocation
Disrupted microbial composition, disrupted intestinal mucus barrier, intestinal permeability, serum LPS, serum zonulin
Metabolic endotoxemia and its broad penalties
That means of meals intolerances—histamine containing meals, nightshades, FODMAPs, fructose, legumes, nuts

Module 6: The microbiome in varied illness states
Gallstones and bacterial infestation
Pancreatic exocrine insufficiency
Gingivitis, periodontitis—together with the colon connection by way of Fusobacterium nucleatum as a explanation for colon most cancers
Irritable bowel syndrome (IBD)
Inflammatory bowel illness
Celiac illness, “non-celiac gluten sensitivity”
Kind 2 diabetes, obese/weight problems
Autoimmune ailments
Neurodegenerative ailments
Heart problems
Issues of being pregnant and lactation
Bariatric procedures together with gastric bypass

Module 7: Strategies of microbiome evaluation
Symptom evaluation
Stool evaluation—reliability, strategies (16S rRNA vs. shotgun metagenomics), microbial analyses, physiologic markers. We evaluate a number of actual world examples throughout completely different testing platforms—e.g., Genova, Ombre, Viome, Intestine Zoomer.
Breath testing—hydrogen, methane, hydrogen sulfide, AIRE machine, Trio-Sensible

Module 8: Give attention to types of overgrowth
Small intestinal bacterial overgrowth (SIBO)—signs; endotoxemia, systemic illness implications; evaluation; eradication; prevention of recurrences
Small intestinal fungal overgrowth (SIFO)—signs; beta glucan, systemic illness implications; evaluation; eradication; prevention of recurrences
Intestinal methanogen overgrowth (IMO)—signs; evaluation; eradication

Module 9: Methods and instruments for microbiome administration
Probiotics–composition, rationale, ineffectiveness; future instructions
Fermented meals–offering the microbiome-”molding” results of essential fermenting species resembling Leuconostoc and Pediococcus species; fundamentals of fermentation
Prebiotic fibers, polysaccharides, polyphenols
Fecal transplant and associated strategies
Restoration of keystone species, higher GI colonization, bacteriocin manufacturing

Closing feedback, overview, future instructions
Assets to observe new developments
Assets for continued suggestions and help
Microbe sources for fermentation
Recipes for chosen microbial ferments

In case you are eager about enrolling on this course (it’s open to non-health coaches, additionally, in addition to docs, different well being professionals, or for anybody eager about an in depth dialogue in regards to the microbiome), enroll right here.

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